Daniel Lefcourt has had solo exhibitions at Sutton Lane Gallery in London and Paris, Gallery Luis Campaña in Berlin, Galerie Mitterrand + Sanz in Zurich, Groeflin Maag in Basel, and at his primary gallery, Taxter & Spengemann in New York. His work has been featured in numerous group exhibitions at galleries and institutions including MoMA PS1, the Sculpture Center, Malmo KonstMuseum and Kunst Werke Berlin.

Lefcourt's work has received critical responses in ArtForum, Frieze, Art in America and The New York Times, among others. He has spoken at institutions including the DIA Center for the Arts, the Cooper Union and at the Bloch Space at the Kansas City Art Institute.

In addition to RISD, Lefcourt has taught at Parsons School of Design, Columbia University, the Cooper Union and the Ontario College of Art and Design.